I agree. I'm sure it's a different animal for an artist who is used to writing his or her own scripts to give up a lot of creative control to another person. It is also more time consuming just because of the number of hours we spend hashing out details over email or IM, hours that an artist working alone doesn't have to spend discussing with himself, unless he has some sort of mental problem.
Anyway, it's a testament to Uroboros's patience and imagination that "Mad Science" turned out as well as it did. The door is certainly open to a sequal if interest from the readers is there..